Table 1.
Weighted means (SE) or percent of study participant characteristics according to SNP rs5918 genotype: The ARIC Carotid MRI Study
| SNP rs5918 genotype |
|||
|---|---|---|---|
| Characteristic | TT (n=1,165) |
TC (n=335) |
CC (n=38) |
| Age (years) | 70.7 (0.2) | 70.6 (0.2) | 70.7 (0.4) |
| Gender (% male) | 44.5 | 46.7 | 49.4 |
| BMI (kg/m2) | 28.4 (0.2) | 27.9 (0.4) | 28.2 (0.9) |
| Glucose (mg/dL) | 106.5 (1.0) | 107.9 (1.6) | 104.7 (3.0) |
| Total cholesterol (mg/dl) | 190.7 (1.6) | 201.1 (3.5) | 179.4 (7.7)* |
| HDL-cholesterol (mg/dL) | 49.6 (0.6) | 50.6 (1.2) | 47.2 (2.4) |
| LDL-cholesterol (mg/DL) | 110.1 (1.5) | 118.2 (3.0) | 101.3 (7.5)* |
| Triglycerides (mg/dL) | 190.7 (1.6) | 201.1 (3.5) | 179.4 (7.7) |
| Diabetes (%) | 19.8 | 22.1 | 20.2 |
| Hypertension (%) | 59.0 | 64.0 | 56.8 |
| Prevalent CHD (%) | 11.6 | 6.8 | 11.1 |
| Use of anticoagulants (%) | 4.6 | 2.1 | 0* |
| Use of anti-hyperlipidemic medication (%) | 47.8 | 37.6 | 35.6 |
| Use of antiplatelet medication (%) | 3.2 | 1.4 | 2.4 |
| Use of aspirin (%) | 54.5 | 47.5 | 55.9 |
| Current smokers (%) | 7.6 | 6.8 | 8.9 |
*
Levels of total cholesterol and LDL-cholesterol were significantly different (p<0.05) between individuals homozygous for the minor allele (CC) and heterozygotes. Use of anticoagulants among those homozygous for the minor allele was significantly different (p<0.05) from anticoagulant use in both the heterozygotes and in the major allele homozygotes. No other statistically significant differences in the distribution of population characteristics were observed.