. Author manuscript; available in PMC: 2012 May 1.

Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2011 Mar 10;20(5):978–989. doi: 10.1158/1055-9965.EPI-10-1089

Table 3.

Cumulative Average Intake of Fat and Risk of Endometrial Cancer, NHS Cohort (1980–2006)

			Age-adjusted model^*		Multi-adjusted model^†		Multi-adjusted model^‡

	# of Cases	Median (g/d)	RR	95% CI	RR	95% CI	RR	95% CI
Total energy (kcal/d)
Q1	110	1024	1.00		1.00
Q2	138	1422	1.27	0.99, 1.63	1.26	0.98, 1.62
Q3	134	1638	1.24	0.96, 1.59	1.23	0.96, 1.59
Q4	156	1882	1.45	1.13, 1.85	1.44	1.13, 1.84
Q5	131	2273	1.24	0.96, 1.59	1.22	0.95, 1.57
P_trend				0.07		0.09
Total fat
Q1	153	50.0	1.00		1.00		1.00
Q2	115	60.5	0.80	0.63, 1.02	0.78	0.61, 1.00	1.11	0.87, 1.42
Q3	151	62.5	1.08	0.86, 1.35	1.02	0.81, 1.28	1.09	0.85, 1.39
Q4	139	67.0	1.02	0.81, 1.29	0.96	0.76, 1.21	1.28	1.01, 1.63
Q5	111	75.4	0.84	0.66, 1.08	0.78	0.60, 0.99	1.17	0.91, 1.49
P_trend				0.55		0.18		0.14
Animal fat
Q1	133	28.0	1.00		1.00		1.00
Q2	144	34.4	1.14	0.90, 1.44	1.07	0.84, 1.35	1.26	0.98, 1.61
Q3	152	38.9	1.21	0.96, 1.53	1.09	0.86, 1.38	1.31	1.03, 1.68
Q4	124	43.3	1.02	0.80, 1.31	0.90	0.70, 1.15	1.23	0.96, 1.58
Q5	116	52.8	0.96	0.75, 1.23	0.84	0.65, 1.08	1.16	0.90, 1.49
P_trend				0.51		0.07		0.51
Vegetable fat
Q1	137	14.1	1.00		1.00		1.00
Q2	151	19.3	1.15	0.91, 1.45	1.14	0.91, 1.44	1.07	0.83, 1.38
Q3	114	22.5	0.88	0.69, 1.13	0.88	0.68, 1.13	1.38	1.09, 1.75
Q4	144	25.7	1.11	0.88, 1.40	1.13	0.90, 1.43	1.19	0.93, 1.52
Q5	123	31.1	0.95	0.74, 1.21	0.99	0.77, 1.26	1.24	0.97, 1.58
P_trend				0.62		0.91		0.08
Saturated fat
Q1	138	17.6	1.00		1.00		1.00
Q2	148	21.1	1.14	0.91, 1.44	1.09	0.86, 1.37	1.02	0.80, 1.31
Q3	136	23.7	1.09	0.86, 1.38	1.01	0.80, 1.29	1.12	0.88, 1.43
Q4	133	25.2	1.10	0.86, 1.40	1.00	0.79, 1.28	1.22	0.96, 1.56
Q5	114	29.3	0.97	0.76, 1.25	0.90	0.70, 1.16	1.11	0.87, 1.42
P_trend				0.75		0.32		0.22
Mono-unsaturated fat
Q1	150	18.9	1.00		1.00		1.00
Q2	128	28.9	0.94	0.74, 1.19	0.92	0.73, 1.17	0.93	0.73, 1.19
Q3	130	24.1	0.94	0.74, 1.19	0.90	0.71, 1.14	1.00	0.79, 1.28
Q4	158	26.1	1.20	0.96, 1.50	1.11	0.89, 1.40	1.18	0.94, 1.49
Q5	103	30.1	0.80	0.62, 1.03	0.74	0.58, 0.96	1.01	0.79, 1.29
P_trend				0.38		0.12		0.43
Poly-unsaturated fat
Q1	127	7.6	1.00		1.00		1.00
Q2	147	9.1	1.20	0.94, 1.52	1.15	0.91, 1.46	1.00	0.77, 1.28
Q3	137	10.1	1.15	0.90, 1.46	1.08	0.85, 1.38	1.23	0.96, 1.56
Q4	131	11.2	1.11	0.87, 1.42	1.04	0.81, 1.33	1.12	0.87, 1.43
Q5	127	13.0	1.11	0.87, 1.42	1.05	0.82, 1.34	1.23	0.96, 1.56
P_trend				0.62		1.00		0.07
Trans fatty acids
Q1	158	2.2	1.00		1.00		1.00
Q2	120	2.9	0.80	0.63, 1.01	0.76	0.60, 0.97	0.85	0.66, 1.09
Q3	139	3.3	0.97	0.77, 1.21	0.91	0.72, 1.14	1.00	0.79, 1.26
Q4	135	3.8	0.95	0.76, 1.20	0.89	0.70, 1.12	1.11	0.90, 1.44
Q5	117	4.7	0.84	0.66, 1.07	0.81	0.63, 1.03	1.01	0.79, 1.28
P_trend				0.40		0.21		0.35
ω-3 fatty acids
Q1	119	0.05	1.00		1.00		1.00
Q2	123	0.10	1.04	0.81, 1.33	1.03	0.80, 1.33	0.99	0.76, 1.27
Q3	125	0.14	0.98	0.76, 1.25	0.93	0.73, 1.20	1.08	0.84, 1.39
Q4	135	0.19	1.07	0.83, 1.36	1.00	0.78, 1.28	0.98	0.76, 1.26
Q5	164	0.29	1.22	0.96, 1.54	1.10	0.87, 1.40	1.18	0.92, 1.49
P_trend				0.07		0.38		0.15

Adjust for age and follow-up period

^†

Adjust for total energy (continuous), smoking [never(reference), past, current], oral contraceptive use [never (reference), < 3 years, 3–5 years, > 5 years], postmenopausal hormone use [premenopausal, postmenopausal never(reference), past, current E only, current E+P], age at menopause [pre/unknown menopause, <45 yr, 45–46 yr, 47–48 yr (reference), 49–50 yr, 51–52 yr, 53+ yr] parity [nulliparous (reference), 1–2 & age at last birth<30, 1–2 & age at last birth>=30, 3–4 & age at last birth<30, 3–4 & age at last birth>=30, 5+], age at menarche [< 12, 12 (reference), > 12], hypertension (yes, no), diabetes (yes, no), BMI (continuous).

^‡

Dietary factors (not energy-adjusted), multivariate-adjusted except for total energy.