Table 4.
Cumulative Average Intake of Dietary Fiber and Carbohydrates and Risk of Endometrial Cancer, NHS Cohort (1980–2006)
| Age-adjusted model* | Multi-adjusted model† | Multi-adjusted model‡ | ||||||
|---|---|---|---|---|---|---|---|---|
| # of Cases | Median (g/d) | RR | 95% CI | RR | 95% CI | RR | 95% CI | |
| Total fiber | ||||||||
| Q1 | 100 | 10.7 | 1.00 | 1.00 | 1.00 | |||
| Q2 | 121 | 13.5 | 1.17 | 0.89, 1.52 | 1.11 | 0.85, 1.45 | 1.35 | 1.03, 1.76 |
| Q3 | 131 | 15.4 | 1.21 | 0.93, 1.57 | 1.11 | 0.85, 1.44 | 1.22 | 0.93, 1.60 |
| Q4 | 151 | 17.5 | 1.31 | 1.02, 1.69 | 1.20 | 0.92, 1.55 | 1.32 | 1.02, 1.72 |
| Q5 | 166 | 21.3 | 1.33 | 1.03, 1.71 | 1.21 | 0.94, 1.57 | 1.54 | 1.19, 1.99 |
| Ptrend | 0.02 | 0.13 | 0.003 | |||||
| Vegetable fiber | ||||||||
| Q1 | 108 | 3.2 | 1.00 | 1.00 | 1.00 | |||
| Q2 | 136 | 4.5 | 1.23 | 0.95, 1.58 | 1.20 | 0.93, 1.54 | 1.43 | 1.10, 1.87 |
| Q3 | 133 | 5.4 | 1.17 | 0.91, 1.51 | 1.14 | 0.88, 1.47 | 1.50 | 1.16, 1.95 |
| Q4 | 133 | 6.4 | 1.13 | 0.87, 1.45 | 1.07 | 0.83, 1.39 | 1.39 | 1.06, 1.81 |
| Q5 | 159 | 8.5 | 1.29 | 1.01, 1.65 | 1.21 | 0.94, 1.55 | 1.46 | 1.12, 1.89 |
| Ptrend | 0.11 | 0.30 | 0.04 | |||||
| Fruit fiber | ||||||||
| Q1 | 111 | 1.4 | 1.00 | 1.00 | 1.00 | |||
| Q2 | 110 | 2.5 | 0.94 | 0.72, 1.22 | 0.86 | 0.66, 1.11 | 1.40 | 1.07, 1.82 |
| Q3 | 135 | 3.6 | 1.10 | 0.85, 1.41 | 0.97 | 0.75, 1.25 | 1.41 | 1.08, 1.83 |
| Q4 | 154 | 4.8 | 1.19 | 0.93, 1.52 | 1.03 | 0.80, 1.32 | 1.49 | 1.15, 1.94 |
| Q5 | 159 | 7.1 | 1.14 | 0.89, 1.46 | 0.97 | 0.76, 1.25 | 1.52 | 1.17, 1.97 |
| Ptrend | 0.11 | 0.69 | 0.09 | |||||
| Cereal fiber | ||||||||
| Q1 | 98 | 1.9 | 1.00 | 1.00 | 1.00 | |||
| Q2 | 133 | 2.8 | 1.34 | 1.03, 1.74 | 1.27 | 0.98, 1.65 | 0.99 | 0.76, 1.30 |
| Q3 | 149 | 3.5 | 1.47 | 1.14, 1.90 | 1.37 | 1.06, 1.77 | 1.13 | 0.87, 1.46 |
| Q4 | 135 | 4.3 | 1.30 | 1.00, 1.68 | 1.22 | 0.94, 1.59 | 1.04 | 0.80, 1.32 |
| Q5 | 154 | 6.0 | 1.38 | 1.07, 1.78 | 1.38 | 1.07, 1.79 | 1.21 | 0.94, 1.56 |
| Ptrend | 0.07 | 0.05 | 0.006 | |||||
| Carbohydrates | ||||||||
| Q1 | 104 | 141.0 | 1.00 | 1.00 | 1.00 | |||
| Q2 | 131 | 166.7 | 1.25 | 0.97, 1.62 | 1.19 | 0.92, 1.55 | 1.35 | 1.04, 1.76 |
| Q3 | 164 | 180.3 | 1.55 | 1.21, 1.99 | 1.51 | 1.18, 1.93 | 1.51 | 1.17, 1.95 |
| Q4 | 128 | 193.3 | 1.19 | 0.92, 1.54 | 1.18 | 0.91, 1.53 | 1.51 | 1.17, 1.96 |
| Q5 | 142 | 214.8 | 1.25 | 0.97, 1.61 | 1.29 | 1.00, 1.67 | 1.51 | 1.17, 1.96 |
| Ptrend | 0.14 | 0.08 | 0.002 | |||||
| Glycemic load | ||||||||
| Q1 | 104 | 72.8 | 1.00 | 1.00 | 1.00 | |||
| Q2 | 145 | 87.3 | 1.36 | 1.06, 1.76 | 1.30 | 1.01, 1.67 | 1.40 | 1.08, 1.82 |
| Q3 | 143 | 95.7 | 1.36 | 1.06, 1.75 | 1.33 | 1.03, 1.71 | 1.52 | 1.17, 1.97 |
| Q4 | 142 | 104.0 | 1.34 | 1.04, 1.72 | 1.33 | 1.03, 1.72 | 1.54 | 1.19, 2.00 |
| Q5 | 135 | 118.3 | 1.25 | 0.97, 1.62 | 1.29 | 0.99, 1.67 | 1.48 | 1.14, 1.92 |
| Ptrend | 0.15 | 0.07 | 0.006 | |||||
Adjust for age and follow-up period
Adjust for total energy (continuous), smoking [never(reference), past, current], oral contraceptive use [never (reference), < 3 years, 3–5 years, > 5 years], postmenopausal hormone use [premenopausal, postmenopausal never(reference), past, current E only, current E+P], age at menopause [pre/unknown menopause, <45 yr, 45–46 yr, 47–48 yr (reference), 49–50 yr, 51–52 yr, 53+ yr] parity [nulliparous (reference), 1–2 & age at last birth<30, 1–2 & age at last birth>=30, 3–4 & age at last birth<30, 3–4 & age at last birth>=30, 5+], age at menarche [< 12, 12 (reference), > 12], hypertension (yes, no), diabetes (yes, no), BMI (continuous).
Dietary factors (not energy-adjusted), multivariable-adjusted.