Table 2. Observed Entrapment Parameters for the 12 Formulations of PB Design.
Formulation Number | Percentage Theoretical Drug Loading | Percentage Actual Drug Loading | Percentage Actual PLGA Loading | Entrapment Efficiency |
---|---|---|---|---|
1 | 20 | 17.3 ± 0.02 | 82.7 | 86.62 ± 0.09 |
2 | 20 | 2.1 ± 0.01 | 97.9 | 10.31 ± 0.04 |
3 | 20 | 2.2 ± 0.00 | 97.8 | 11.17 ± 0.00 |
4 | 11.1 | 5.5 ± 0.00 | 94.5 | 49.26 ± 0.02 |
5 | 11.1 | 7.3 ± 0.01 | 92.7 | 65.74 ± 0.13 |
6 | 11.1 | 2.6 ± 0.00 | 97.4 | 23.25 ± 0.04 |
7 | 33.3 | 31.0 ± 0.03 | 69.0 | 93.07 ± 0.08 |
8 | 33.3 | 29.2 ± 0.02 | 70.8 | 87.68 ± 0.05 |
9 | 33.3 | 10.8 ± 0.00 | 89.2 | 32.35 ± 0.01 |
10 | 20 | 17.5 ± 0.01 | 82.5 | 87.44 ± 0.03 |
11 | 20 | 4.6 ± 0.01 | 95.4 | 23.22 ± 0.06 |
12 | 20 | 2.0 ± 0.01 | 98.0 | 10.62 ± 0.06 |