FIGURE 8. IL-17 secretion correlates with T2D disease severity.

A, Comparison of all ND and T2D donors described in Table I based on BMI (left panel) or age (right panel). Significant differences between ND and T2D cohorts were calculated by the Mann–Whitney U test. B, Relationship between age (x-axis) and percentage of CD3⁺CCR4⁺CCR6⁺ cells (y-axis). C, Relationship between hemoglobin A1c, a marker of diabetes severity (HBA1c; x-axis) and secreted IL-17 protein (y-axis). The p values indicated in B and C were calculated using Pearson’s correlation; r² values are shown below p values.