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. 2011 Apr 16;11:140. doi: 10.1186/1471-2407-11-140

Figure 1.

Figure 1

Design of the NNBC 3-Europe trial. Stratification and randomization schedule: C1 = stratification by type of risk assessment based on choice of the centre (type of risk assessment); C2 = stratification by risk status; S = Stratification by HER-2/neu-FISH result; R = randomisation (FE100C: 5-Fluorouracil 500 mg/m², Epirubicin 100 mg/m², Cyclophosphamide 500 mg/m², q3 wks; Doc: Docetaxel 100 mg/m², q3 wks.). += fresh tumour tissue for patients within the "biological UP pathway", additionally in all patients paraffin blocks for central review.