Table 5.
Functional enrichment analysis of differentially regulateda genes elicited by TCDD in Hepa1c1c7 cells using DAVID.
| Category | Term | Gene count | Fold enrichment | P-value |
|---|---|---|---|---|
| Enrichment Score: 18.67 | ||||
| GOTERM_BP_3 | GO:0000278 ~ mitotic cell cycle | 43 | 5.95 | 7.67E-21 |
| GOTERM_BP_3 | GO:0022402 ~ cell cycle process | 52 | 4.50 | 1.15E-19 |
| GOTERM_BP_3 | GO:0022403 ~ cell cycle phase | 47 | 4.87 | 3.67E-19 |
| GOTERM_BP_3 | GO:0048285 ~ organelle fission | 36 | 6.14 | 6.31E-18 |
| Enrichment Score: 2.05 | ||||
| GOTERM_BP_3 | GO:0006805 ~ xenobiotic metabolic process | 4 | 11.20 | 4.67E-03 |
| GOTERM_BP_3 | GO:0009410 ~ response to xenobiotic stimulus | 4 | 8.96 | 9.05E-03 |
| GOTERM_BP_3 | GO:0006725 ~ cellular aromatic compound metabolic process | 9 | 2.75 | 1.66E-02 |
| Enrichment Score: 2.04 | ||||
| GOTERM_BP_3 | GO:0048522 ~ positive regulation of cellular process | 58 | 1.51 | 1.41E-03 |
| GOTERM_BP_3 | GO:0042127 ~ regulation of cell proliferation | 27 | 1.72 | 7.62E-03 |
| GOTERM_BP_3 | GO:0008284 ~ positive regulation of cell proliferation | 14 | 1.69 | 7.12E-02 |
| Enrichment Score: 1.62 | ||||
| GOTERM_BP_3 | GO:0051640 ~ organelle localization | 7 | 4.36 | 5.10E-03 |
| GOTERM_BP_3 | GO:0051651 ~ maintenance of location in cell | 4 | 5.38 | 3.68E-02 |
| GOTERM_BP_3 | GO:0051235 ~ maintenance of location | 4 | 4.07 | 7.35E-02 |
aDifferentially regulated genes with P1(t) > 0.999 and |foldchange| > 1.4