Table 6.
Functional enrichment analysis of differentially regulateda genes elicited by TCDD in H4IIE cells using DAVID.
| Category | Term | Gene count | Fold enrichment | P-value |
|---|---|---|---|---|
| Enrichment Score: 3.05 | ||||
| GOTERM_BP_3 | GO:0006805 ~ xenobiotic metabolic process | 7 | 34.21 | 3.52E-08 |
| GOTERM_BP_3 | GO:0009410 ~ response to xenobiotic stimulus | 7 | 31.47 | 6.09E-08 |
| GOTERM_BP_3 | GO:0006725 ~ cellular aromatic compound metabolic process | 6 | 5.07 | 6.28E-03 |
| GOTERM_BP_3 | GO:0017144 ~ drug metabolic process | 3 | 16.86 | 1.31E-02 |
| GOTERM_BP_3 | GO:0051186 ~ cofactor metabolic process | 6 | 3.61 | 2.44E-02 |
| GOTERM_BP_3 | GO:0046483 ~ heterocycle metabolic process | 5 | 1.78 | 3.03E-01 |
| GOTERM_BP_3 | GO:0044248 ~ cellular catabolic process | 8 | 1.39 | 3.41E-01 |
| Enrichment Score: 2.45 | ||||
| GOTERM_BP_3 | GO:0010035 ~ response to inorganic substance | 11 | 4.70 | 1.00E-04 |
| GOTERM_BP_3 | GO:0006800 ~ oxygen and reactive oxygen species metabolic process | 5 | 10.81 | 1.10E-03 |
| GOTERM_BP_3 | GO:0006979 ~ response to oxidative stress | 7 | 4.50 | 4.38E-03 |
| GOTERM_BP_3 | GO:0044248 ~ cellular catabolic process | 8 | 1.39 | 3.41E-01 |
| Enrichment Score: 1.59 | ||||
| GOTERM_BP_3 | GO:0006629 ~ lipid metabolic process | 14 | 2.49 | 3.37E-03 |
| GOTERM_BP_3 | GO:0006082 ~ organic acid metabolic process | 12 | 2.71 | 4.12E-03 |
| GOTERM_BP_3 | GO:0042180 ~ cellular ketone metabolic process | 12 | 2.68 | 4.57E-03 |
| GOTERM_BP_3 | GO:0044255 ~ cellular lipid metabolic process | 11 | 2.77 | 5.68E-03 |
| GOTERM_BP_3 | GO:0005996 ~ monosaccharide metabolic process | 7 | 4.23 | 5.88E-03 |
| GOTERM_BP_3 | GO:0016051 ~ carbohydrate biosynthetic process | 5 | 6.18 | 8.38E-03 |
| GOTERM_BP_3 | GO:0044262 ~ cellular carbohydrate metabolic process | 7 | 2.63 | 4.80E-02 |
| GOTERM_BP_3 | GO:0046165 ~ alcohol biosynthetic process | 3 | 8.03 | 5.25E-02 |
| GOTERM_BP_3 | GO:0005975 ~ carbohydrate metabolic process | 8 | 2.25 | 6.22E-02 |
| GOTERM_BP_3 | GO:0006091 ~ generation of precursor metabolites and energy | 5 | 2.70 | 1.11E-01 |
| GOTERM_BP_3 | GO:0008610 ~ lipid biosynthetic process | 4 | 1.71 | 4.09E-01 |
| GOTERM_BP_3 | GO:0044249 ~ cellular biosynthetic process | 16 | 1.04 | 5.74E-01 |
| Enrichment Score: 1.58 | ||||
| GOTERM_BP_3 | GO:0042493 ~ response to drug | 11 | 3.94 | 4.20E-04 |
| GOTERM_BP_3 | GO:0006869 ~ lipid transport | 4 | 3.91 | 8.07E-02 |
| GOTERM_BP_3 | GO:0010876 ~ lipid localization | 4 | 3.54 | 1.01E-01 |
| GOTERM_BP_3 | GO:0042592 ~ homeostatic process | 10 | 1.66 | 1.39E-01 |
| Enrichment Score: 1.54 | ||||
| GOTERM_BP_3 | GO:0044255 ~ cellular lipid metabolic process | 11 | 2.77 | 5.68E-03 |
| GOTERM_BP_3 | GO:0006721 ~ terpenoid metabolic process | 3 | 10.54 | 3.20E-02 |
| GOTERM_BP_3 | GO:0006766 ~ vitamin metabolic process | 3 | 4.75 | 1.29E-01 |
aDifferentially regulated genes with P1(t) > 0.999 and |foldchange| > 1.4