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. Author manuscript; available in PMC: 2012 Mar 19.
Published in final edited form as: ChemMedChem. 2010 Dec 29;6(2):362–377. doi: 10.1002/cmdc.201000475

Table 5.

Biological evaluation of furan and furan-related NTZ analogues.

graphic file with name nihms263549u5.jpg
Analogue[a] MIC’s (μM) Analogue[a] MIC’s (μM)
H. pylori C. jejuni H. pylori C. jejuni
NTZ (1) 13.0 39.1 NTZ (1) 13.0 39.1
60 0.8 12.5 67 1.5 24.0
61 1.0 8.4 68 1.1 8.5
62 1.6 12.6 69 6.9 16.7
63 2.8 20.2 70 1.6 13.1
64 21.1 7.0 71 6.2 99.6
65 2.4 101.5 72 0.6 110.6
66 1.1 22.9 73 4.5 4.5
[a]

R = H unless otherwise noted.