Table 5.
Biological evaluation of furan and furan-related NTZ analogues.
![]() | |||||
|---|---|---|---|---|---|
| Analogue[a] | MIC’s (μM) | Analogue[a] | MIC’s (μM) | ||
| H. pylori | C. jejuni | H. pylori | C. jejuni | ||
| NTZ (1) | 13.0 | 39.1 | NTZ (1) | 13.0 | 39.1 |
| 60 | 0.8 | 12.5 | 67 | 1.5 | 24.0 |
| 61 | 1.0 | 8.4 | 68 | 1.1 | 8.5 |
| 62 | 1.6 | 12.6 | 69 | 6.9 | 16.7 |
| 63 | 2.8 | 20.2 | 70 | 1.6 | 13.1 |
| 64 | 21.1 | 7.0 | 71 | 6.2 | 99.6 |
| 65 | 2.4 | 101.5 | 72 | 0.6 | 110.6 |
| 66 | 1.1 | 22.9 | 73 | 4.5 | 4.5 |
R = H unless otherwise noted.
