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Biological evaluation of thiophene and related NTZ analogues.
 | |||||
|---|---|---|---|---|---|
| Analogue[a] | MIC’s (μM) | Analogue[a] | MIC’s (μM) | ||
| H. pylori | C. jejuni | H. pylori | C. jejuni | ||
| NTZ (1) | 13.0 | 39.1 | NTZ (1) | 13.0 | 39.1 |
| 74 | 0.7 | 5.9 | 81 | 0.7 | 5.5 |
| 75 | 1.5 | 2.3 | 82 | 3.0 | 94.8 |
| 76 | 2.9 | 2.9 | 83 | 7.8 | 12.4 |
| 77 | 5.2 | 6.9 | 84 | 2.5 | 9.8 |
| 78 | 5.2 | 20.7 | 85 | 2.2 | 5.9 |
| 79 | 3.0 | 9.9 | 86 | 1.0 | 5.6 |
| 80 | 1.5 | 72.4 | - | - | - |
R = H unless otherwise noted.
