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. Author manuscript; available in PMC: 2012 Jun 1.
Published in final edited form as: Biol Psychiatry. 2011 Jan 8;69(11):1035–1042. doi: 10.1016/j.biopsych.2010.11.025

Figure 2. Effects of cocaine on palmitoylation of AMPAR subunits GluA1-4 in the rat NAc.

Figure 2

(A–D) Effects of cocaine at different doses on palmitoylation of GluA1 (A), GluA2 (B), GluA3 (C), and GluA4 (D) in the NAc. Representative immunoblots from rats receiving 20 mg/kg of cocaine are shown left to the quantified data. Note that cocaine at the two higher doses increased palmitoylation of GluA1 and GluA3, but not GluA2 and GluA4. (E and F) Effects of cocaine on motor activities in terms of horizontal locomotor activity (E) and stereotypy time (F). Rats were given a single dose of cocaine or saline and sacrificed 30 min after injection (A–D). Motor responses to cocaine or saline were continuously measured for 30 min (E and F). Data are presented as means ± SEM (n = 4–8 per group). *P < .05 and **P < .01 versus saline (Student t test).