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. Author manuscript; available in PMC: 2012 Jun 1.
Published in final edited form as: Biol Psychiatry. 2011 Jan 8;69(11):1035–1042. doi: 10.1016/j.biopsych.2010.11.025

Figure 3. Time-dependent effects of cocaine on palmitoylation of AMPAR subunits GluA1-4 in the rat NAc.

Figure 3

(A–D) Time-dependent effects of cocaine on palmitoylation of GluA1 (A), GluA2 (B), GluA3 (C), and GluA4 (D) in the NAc. Representative immunoblots are shown left to the quantified data. Note that cocaine time-dependently increased palmitoylation of GluA1 and GluA3, but not GluA2 and GluA4. (E and F) Temporal effects of cocaine on motor activities in terms of horizontal locomotor activity (E) and stereotypy time (F). Rats were given a single dose of cocaine (20 mg/kg, i.p.) or saline and sacrificed at different time points (15, 30, or 90 min after drug injection) for ABE assays of changes in GluA1-4 palmitoylation (A–D). For rats sacrificed at 90 min, their motor responses to cocaine or saline in terms of horizontal locomotor activity (E) and stereotypy time (F) were continuously measured for 60 min. Data are presented as means ± SEM (n = 5–7 per group). **P < .01 versus saline (Student t test).