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. Author manuscript; available in PMC: 2012 Jun 1.
Published in final edited form as: Biol Psychiatry. 2011 Jan 8;69(11):1035–1042. doi: 10.1016/j.biopsych.2010.11.025

Figure 5. Effects of cocaine on surface and intracellular expression of AMPAR subunits in rat NAc neurons.

Figure 5

(A–H) Effects of saline (Sal) or cocaine (Coc) on surface (S) and intracellular (I) expression of GluA1 (A), GluA2 (C), GluA3 (E), and GluA4 (G) and on the S:I ratio of GluA1 (B), GluA2 (D), GluA3 (F), and GluA4 (H) in NAc neurons. (I) Effects of saline and cocaine on expression of α-actinin. Rats were given a single dose of cocaine (20 mg/kg, i.p.) or saline. They were sacrificed 30 min after drug injection for BS3 crosslinking assays of changes in surface versus intracellular expression of GluA1-4 in the NAc. Representative immunoblots are shown to the left of the quantified date (A, C, E, G, and I). Data are presented as means ± SEM (n = 6 per group). *P < .05 versus saline (Student t test).