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. Author manuscript; available in PMC: 2012 Jun 1.
Published in final edited form as: Biol Psychiatry. 2011 Jan 8;69(11):1035–1042. doi: 10.1016/j.biopsych.2010.11.025

Figure 6. Effects of 2-BP on cocaine-stimulated palmitoylation and redistribution of GluA1/3 in rat NAc neurons and on behavioral responses to cocaine.

Figure 6

(A and B) Effects of 2-BP on cocaine-stimulated palmitoylation and redistribution of GluA1 (A) and GluA3 (B) in the NAc. Data were analyzed with one-way ANOVA: palmitoylation, surface and intracellular GluA1 for F(3,20) = 9.9, F(3,20) = 6.8 and F(3,20) = 15.2, respectively; P < .05, and GluA3 for F(3,20) = 10.2, F(3,20) = 7.1 and F(3,20) = 29.1, respectively; P < .05. (C) Intra-NAc injection of 2-BP augmented the cocaine-stimulated horizontal activity. Data were analyzed with two-way ANOVA [drug F(3,28) = 31.7, P < .05; time F(11,308) = 16.8, P < .05; interaction F(33,308) = 3.8, P < .05]. (D) A graph of the data from (C) obtained during 60 min after i.p. injection of saline or cocaine. Vehicle or 2-BP (0.3 nmol/0.5 μl) was injected into bilateral NAc 1 h prior to an i.p. injection of saline or cocaine (20 mg/kg, i.p.). Data are presented as means ± SEM. *P < .05 versus vehicle + saline. +P < .05 versus vehicle + cocaine.