TABLE 2.
IRs of Hypercholesterolemia by Selected Characteristics (N = 2122)
| Characteristic | Number | Events | Person-Years | IR per 100 Person-Years (95% CI) |
|---|---|---|---|---|
| Overall rate | 2122 | 277 | 8058.7 | 3.4 (3.0 to 3.9) |
| Baseline age (y) | ||||
| <6 | 480 | 76 | 1792.6 | 4.2 (3.3 to 5.3) |
| 6 to 9 | 693 | 102 | 2746.6 | 3.7 (3.0 to 4.5) |
| 10 to 12 | 535 | 65 | 2048.5 | 3.2 (2.5 to 4.0) |
| ≥13 | 414 | 34 | 1471.0 | 2.3 (1.6 to 3.2) |
| Baseline viral load* | ||||
| ≤400 | 767 | 119 | 2903.0 | 4.1 (3.4 to 4.9) |
| 401 to 5000 | 503 | 61 | 1924.3 | 3.2 (2.4 to 4.1) |
| 5001 to 50,000 | 515 | 57 | 2022.3 | 2.8 (2.1 to 3.6) |
| >50,000 | 272 | 34 | 940.2 | 3.6 (2.5 to 5.0) |
| PI use at baseline | ||||
| No | 680 | 49 | 2657.8 | 1.8 (1.4 to 2.4) |
| Yes, nonboosted | 1027 | 174 | 3957.4 | 4.4 (3.8 to 5.1) |
| Yes, boosted | 415 | 54 | 1443.5 | 3.7 (2.8 to 4.9) |
| NNRTIs at baseline | ||||
| No | 1404 | 180 | 5275.6 | 3.4 (2.9 to 3.9) |
| Yes | 718 | 97 | 2783.1 | 3.5 (2.8 to 4.2) |
| NRTIs at baseline | ||||
| None | 93 | 6 | 323.5 | 1.8 (0.7 to 4.0) |
| 1 | 343 | 64 | 1299.6 | 4.9 (3.8 to 6.3) |
| ≥2 | 1686 | 207 | 6435.6 | 3.2 (2.8 to 3.7) |
| Baseline HAART use | ||||
| HAART with PI | 1412 | 218 | 5307.2 | 4.1 (3.6 to 4.7) |
| HAART without PI | 250 | 13 | 966.5 | 1.3 (0.7 to 2.3) |
| ART without HAART | 378 | 42 | 1505.0 | 2.8 (2.0 to 3.8) |
| No ART | 82 | 4 | 280.0 | 1.4 (0.4 to 3.7) |
| Time-dependent HAART use† | ||||
| HAART with PI | 1662 | 248 | 5182.9 | 4.8 (4.2 to 5.4) |
| HAART without PI | 459 | 7 | 949.5 | 0.7 (0.3 to 1.5) |
| ART without HAART | 640 | 19 | 1330.8 | 1.4 (0.9 to 2.2) |
| No ART | 594 | 3 | 595.5 | 0.5 (0.1 to 1.5) |
| Blinded | 1 | 0 | 0.008 | 0.0 (0.0 to 0.005)‡ |
*
Sixty-five children were missing a baseline viral load.
†
Numbers do not add up to 2122, because children can contribute time to more than 1 exposure group during follow-up.
‡
One-sided, 97.5% CI.