Table 3.
Genes with diverse cellular functions (n=56) that have altered expression in thyroid tumors of ThrbPV/PV mice
| Gene symbol | Gene name | Fold change |
|---|---|---|
| Ca4* | carbonic anhydrase IV | 6.69 |
| Got1* | glutamic-oxaloacetic transaminase 1, soluble (aspartate aminotransferase 1) | 5.78 |
| Ppp2r3a | protein phosphatase 2 (formerly 2A), regulatory subunit B, alpha | 4.64 |
| Sbf1 | SET binding factor 1 | 4.39 |
| Slc22a23 | solute carrier family 22, member 23 | 3.28 |
| Fxyd4 | FXYD domain containing ion transport regulator 4 | 3.11 |
| Kif5c* | kinesin family member 5C | 2.94 |
| Rbm20 | RNA binding motif protein 20 | 2.91 |
| Pcbd1* | pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha | 2.86 |
| Dusp14 | dual specificity phosphatase 14 | 2.79 |
| Suclg2 | succinate-CoA ligase, GDP-forming, beta subunit | 2.78 |
| Mtm1 | myotubularin 1 | 2.73 |
| B3gnt1 | UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 1 | 2.65 |
| Trpm3 | transient receptor potential cation channel, subfamily M, member 3 | 2.53 |
| Rcor1 | REST corepressor 1 | 2.49 |
| Socs1* | suppressor of cytokine signaling 1 | 2.47 |
| Lsm2 | LSM2 homolog, U6 small nuclear RNA associated (S. cerevisiae) | 2.47 |
| Dync1i1* | dynein, cytoplasmic 1, intermediate chain 1 | 2.35 |
| Fut9 | fucosyltransferase 9 (alpha (1,3) fucosyltransferase) | 2.32 |
| Rtn4ip1 | reticulon 4 interacting protein 1 | 2.30 |
| Rnasek | ribonuclease, RNase K | 2.09 |
| Lonp1 | lon peptidase 1, mitochondrial | 2.08 |
| Map6d1 | MAP6 domain containing 1 | 1.95 |
| Hira | HIR histone cell cycle regulation defective homolog A (S. cerevisiae) | 1.94 |
| Ppif | peptidylprolyl isomerase F | 1.88 |
| Arl13b | ADP-ribosylation factor-like 13B | 1.86 |
| Med20 | mediator complex subunit 20 | 1.76 |
| Flrt1 | fibronectin leucine rich transmembrane protein 1 | 1.64 |
| Usp3* | ubiquitin specific peptidase 3 | 1.56 |
| Dph2 | DPH2 homolog (S. cerevisiae) | 1.51 |
| Gbf1* | golgi-specific brefeldin A resistant guanine nucleotide exchange factor 1 | 1.51 |
| Otud7a* | OTU domain containing 7A | 0.65 |
| Rnf130 | ring finger protein 130 | 0.64 |
| Sp3* | Sp3 transcription factor | 0.60 |
| Rpl11 | ribosomal protein L11 | 0.59 |
| N6amt2 | N-6 adenine-specific DNA methyltransferase 2 (putative) | 0.58 |
| Gfod1 | glucose-fructose oxidoreductase domain containing 1 | 0.58 |
| Foxn3 | forkhead box N3 | 0.57 |
| Mbd5 | methyl-CpG binding domain protein 5 | 0.57 |
| Pnliprp2 | pancreatic lipase-related protein 2 | 0.56 |
| Tacr3 | tachykinin receptor 3 | 0.54 |
| Trove2 | TROVE domain family, member 2 | 0.50 |
| Oxtr | oxytocin receptor | 0.48 |
| Tgs1 | trimethylguanosine synthase homolog (S. cerevisiae) | 0.47 |
| Usp37* | ubiquitin specific peptidase 37 | 0.46 |
| Tbc1d20* | TBC1 domain family, member 20 | 0.45 |
| Rpl37 | ribosomal protein L37 | 0.45 |
| Fjx1 | four jointed box 1 (Drosophila) | 0.44 |
| Golim4* | golgi integral membrane protein 4 | 0.41 |
| Olfm1 | olfactomedin 1 | 0.37 |
| Taok1 | TAO kinase 1 | 0.35 |
| Cldnd1 | claudin domain containing 1 | 0.35 |
| Ggps1 | geranylgeranyl diphosphate synthase 1 | 0.31 |
| Rc3h2 | ring finger and CCCH-type zinc finger domains 2 | 0.30 |
| Tor1b | torsin family 1, member B (torsin B) | 0.28 |
| Zranb1* | zinc finger, RAN-binding domain containing 1 | 0.21 |
*
Genes discussed in the text.