Supplementary Table 3.
Functional analysis of genes (n=150) with aberrant expression in thyroid tumors of ThrbPV/PV mice
| Sub-Category | p-value | Molecules | |
|---|---|---|---|
| Cell development and differentiation | Reproductive System Development and Function | 1.36E-04-4.4E-02 | MUC4, OXTR, IL11, AFP, HIRA, SLC12A2, KRT8, ESRRB, DDR1, SOCS1, SP3, SHH |
| Embryonic Development | 6.01E-04-4.4E-02 | ARL13B, IL11, HIRA, HNF1B, MAP3K2, KRT8, ESRRB, HMGA1, GRHL3, SHH | |
| Digestive System Development and Function | 1.42E-03-3.78E-02 | HNF1B, SLC12A2, GFRA1, SPTBN1, SHH | |
| Hematological System Development and Function | 2.16E-03-4.4E-02 | IL11, ROCK1, FGG, MAP3K2, ATRN, DDR1, THY1, SOCS1, HMGA1, SP3, SHH | |
| Renal and Urological System Development and Function | 6.25E-03-4.4E-02 | IL11, HNF1B, GFRA1, THY1, SHH | |
| Nervous System Development and Function | 4.61E-03-4.4E-02 | OLFM1, ROCK1, RFX4, ATRN, GFRA1, SHH, KIF5C, MT3, IL11, HNF1B, FUT9, ALCAM, RTN4, THY1, NR2F2 | |
| Connective Tissue Development and Function | 6.14E-03-4.4E-02 | MIA, IL11, ROCK1, KRT8, RTN4, THY1, SHH | |
| Endocrine System Development and Function | 6.41E-03-4.4E-02 | AFP, KRT8, SLC5A5, SOCS1, HMGA1, SHH | |
| Cardiovascular System Development and Function | 6.41E-03-3.78E-02 | HNF1B, DDR1, RTN4, IL13RA2, THY1, NR2F2, SHH | |
| Disease-related | Gastrointestinal Disease | 2.56E-04-2.54E-02 | RFX4, TACR3, ESRRB, IL13RA2, SOCS1, LAMC2, GFRA1, TRPM3, SAMD12, SP3, SHH, GFOD1, USP3, IL11, GOT1, SUCLG2, HIRA, DYNC1I1, KRT8, ALCAM, FOXN3 |
| Genetic Disorder | 1.77E-03-4.4E-02 | PSD3, TTC13, ATRN, TRPM3, RRN3, SP3, SLC39A4, SHH, USP3, FSTL1, MT3, SUCLG2, HIRA, ALCAM, FOXN3, RTN4, RFX5, SLC22A23, MATR3, LMAN1, MBD5, RNF130, TACR3, PDLIM4, GFRA1, GOT1, DYNC1I1, FUT9, THY1, B3GNT1, GBF1, DDR1, SAMD12, CA4, PCBD1, ATXN2, HNF1B, FGG, CYB5B, GRHL2, OLFM1, RFX4, SLC12A2, TAOK1, ZRANB1, ESRRB, MTM1, SLC5A5, IL13RA2, SOCS1, LAMC2, GFOD1, TOMM40, KRT8, HMGA1, SPTBN1 | |
| Renal and Urological Disease | 1.77E-03-1.91E-02 | HNF1B, DDR1, SOCS1 | |
| Endocrine System Disorders | 3.04E-03-3.16E-02 | PSD3, TTC13, GBF1, DDR1, TRPM3, SAMD12, USP3, CA4, HNF1B, ATXN2, LSM2, GRHL2, ALCAM, FOXN3, TROVE2, RFX4, OTUD7A, PDLIM4, SLC5A5, LAMC2, SOCS1, DYNC1I1, FUT9, THY1, SPTBN1 | |
| Auditory Disease | 5.57E-03-1.91E-02 | SLC12A2, GRHL2, ESRRB | |
| Inflammatory Disease | 3.65E-03-4.4E-02 | PSD3, DDR1, RCOR1, SAMD12, TRPM3, SP3, RRN3, SHH, USP3, CA4, HIRA, SUCLG2, FGG, LSM2, CYB5B, ALCAM, FOXN3, PNLIPRP2, GRHL3, RFX4, ZRANB1, ESRRB, IL13RA2, SOCS1, GFRA1, LAMC2, GOT1, DYNC1I1, GOLIM4 | |
| Cell structure and mobility | Cell-To-Cell Signaling and Interaction | 1.11E-03-4.4E-02 | MUC4, ROCK1, ATRN, DDR1, B4GALNT2, SOCS1, GFRA1, LAMC2, SHH, OXTR, IL11, FGG, KRT8, MAP3K2, ALCAM, THY1 |
| Tissue Morphology | 6.01E-04-4.4E-02 | MIA, SLC12A2, ESRRB, DDR1, GFRA1, SOCS1, SHH, KIF5C, IL11, HIRA, HNF1B, KRT8, THY1 | |
| Cell Morphology | 1.42E-03-4.4E-02 | MIA, TMOD3, ROCK1, GBF1, TAOK1, KRT8, ATRN, RTN4, SOCS1, SHH | |
| Cellular Movement | 4.61E-03-4.2E-02 | CXCL17, MIA, ROCK1, DDR1, LAMC2, SOCS1, GFRA1, SHH, FSTL1, KIF5C, IL11, TMOD3, MAP3K2, ALCAM, RTN4, THY1, NR2F2 | |
| Cellular Assembly and Organization | 6.41E-03-4.4E-02 | MIA, ROCK1, TAOK1, MAP6D1, LAMC2, SOCS1, RRN3, SHH, HNF1B, FGG, KRT8, RTN4, RPL11, SPTBN1 | |
| Tumor Morphology | 1.28E-02-2.54E-02 | GFRA1, HMGA1, SHH | |
| Immune response | Infection Mechanism | 1.11E-03-1.28E-02 | IL11, HMGA1 |
| Cell-mediated Immune Response | 2.16E-03-3.16E-02 | MAP3K2, SOCS1, HMGA1, SHH | |
| Hypersensitivity Response | 6.41E-03-4.4E-02 | IL11, SOCS1 | |
| Inflammatory Response | 6.41E-03-3.23E-02 | IL11, KRT8, ATRN, DDR1, ALCAM, SOCS1 | |
| Antimicrobial Response | 1.28E-02-2.54E-02 | MT3, SOCS1 | |
| Immune Cell Trafficking | 1.28E-02-2.52E-02 | IL11, ROCK1, FGG, MAP3K2, THY1 | |
| Cell growth or death | Cellular Growth and Proliferation | 2.16E-03-4.4E-02 | MUC4, MT3, IL11, SLC12A2, PDLIM4, GFRA1, SOCS1, HMGA1, SHH |
| Cell Death | 2.74E-03-4.4E-02 | PPIF, ROCK1, DDR1, RRN3, SP3, SHH, MT3, FSTL1, IL11, AFP, ATXN2, ALCAM, RTN4, MIA, RPL37, SLC12A2, PDLIM4, SLC5A5, GFRA1, SOCS1, SRA1, KRT8, MAP3K2, EMP2, THY1, HMGA1 | |
| Cell Cycle | 6.41E-03-3.16E-02 | GFRA1, SOCS1, HMGA1, SHH | |
| DNA Replication, Recombination, and Repair | 6.41E-03-6.41E-03 | HIRA, HMGA1 | |
| Metabolism-related | Amino Acid Metabolism | 1.24E-02-4.03E-02 | GOT1, IL11, SBF1, ROCK1, FUT9, MAPK6, TAOK1, MAP3K2, DDR1, B4GALNT2 |
| Carbohydrate Metabolism | 1.28E-02-4.4E-02 | MTM1, B4GALNT2, SOCS1 | |
| Lipid Metabolism | 1.28E-02-3.78E-02 | HNF1B, MTM1, SEC14L2, PNLIPRP2 | |
| Vitamin and Mineral Metabolism | 1.28E-02-1.28E-02 | SEC14L2 | |
| Nucleic Acid Metabolism | 3.16E-02-3.16E-02 | B4GALNT2 |