Table 2.
Composition of the TF families of the modules. Each TF family consists of several transcription factors (TFs). Additional information about description and binding domains of the families is given in the second and fourth column, respectively.
| TF family | Description | TFs | Binding domains |
|---|---|---|---|
| CTCF | CTCF and BORIS gene family, transcriptional regulators with 11 highly conserved zinc finger domains | CTCF, CTCFL | C2H2 zinc finger domain |
| E2FF | E2F-myc activator/cell cycle regulator | E2F1, E2F2, E2F3, E2F4, E2F5, E2F6, E2F7, E2F8, TFDP1, TFDP2, TFPD3 | E2F winged helix |
| EGRF | EGR/nerve growth factor-induced protein C and related factors | EGR1, EGR2, EGR3, EGR4, WT1, ZBTB7A, ZBTB7B | C2H2 zinc finger domain |
| HAND | Twist subfamily of class B bHLH transcription factors | HAND1, HAND2, LYL1, MESP1, MESP2, NHLH1, NHLH2, SCXA, SCXB, TAL1, TAL2, TCF12, TCF15, TCF3, TWIST1, TWIST2 | bHLH |
| KLFS | Krueppel-like transcription factors | KLF1, KLF2, KLF3, KLF4, KLF6, KLF7, KLF8, KLF9, KLF12, KLF13, KLF15 | — |
| NRF1 | Nuclear respiratory factor 1 | NRF1 | bZIP |
| SP1F | GC-Box factors SP1/GC | KLF10, KLF11, KLF16, KLF5, SP1, SP2, SP3, SP4, SP5, SP6, SP7, SP8 | C2H2 zinc finger domain |
| ZBPF | Zinc binding protein factors | ZKSCAN3, ZNF148, ZNF202, ZNF219, ZNF281, ZNF300 | C2H2 zinc finger domain |