Figure 3.

Effect of combined therapy of methotrexate and stobadine on hind paw volume assessed on day 28. Values are given as arithmetic mean ± S.E.M. Statistical significance was evaluated using unpaired Student′s t-test: ***p<0.001 with respect to control healthy animals, +p<0.05 with respect to untreated arthritic animals and #p<0.05 for comparison of methotrexate monotherapy with combined therapy. The experiment included healthy control animals (HC), arthritic animals without any drug administration (AA), and arthritic animals with the administration of methotrexate (AA-Mtx) and combination of methotrexate and stobadine (AA-Stb+Mtx).