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. 2011 Mar;4(1):33–39. doi: 10.2478/v10102-011-0007-9

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Copyright © 2011 Slovak Toxicology Society SETOX

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effect of combined therapy of methotrexate and pinosylvin on hind paw volume assessed on day 28. Values are given as arithmetic mean ± S.E.M. Statistical significance was evaluated using unpaired Student′s t-test: ***p<0.001 with respect to control healthy animals, +++p<0.001 with respect to untreated arthritic animals. The experiment included healthy control animals (HC), arthritic animals without any drug administration (AA), and arthritic animals with the administration of pinosylvin (AA-Pin), methotrexate (AA-Mtx) and combination of methotrexate and pinosylvin (AA-Pin+Mtx).