Figure 5.

Effect of combined therapy of methotrexate and coenzyme Q₁₀ on plasmatic level of IL-1α assessed on day 28. Values are given as arithmetic mean ± S.E.M. Statistical significance was evaluated using unpaired Student′s t-test: **p<0.01 with respect to control healthy animals, ++p<0.01 with respect to untreated arthritic animals and ##p<0.01 for comparison of methotrexate monotherapy with combined therapy. The experiment included healthy control animals (HC), arthritic animals without any drug administration (AA), and arthritic animals with the administration of coenzyme Q₁₀ (AA-CoQ), methotrexate (AA-Mtx) and combination of methotrexate and coenzyme Q₁₀ (AA-CoQ+Mtx).