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. 2011 Mar;4(1):33–39. doi: 10.2478/v10102-011-0007-9

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Copyright © 2011 Slovak Toxicology Society SETOX

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Effect of combined therapy of methotrexate and pinosylvin on plasmatic level of TBARS assessed on day 28. Values are given as arithmetic mean ± S.E.M. Statistical significance was evaluated using unpaired Student′s t-test: ***p<0.001 with respect to control healthy animals, +++p<0.001 with respect to untreated arthritic animals and #p<0.05 for comparison of methotrexate monotherapy with combined therapy. The experiment included healthy control animals (HC), arthritic animals without any drug administration (AA), and arthritic animals with the administration of pinosylvin (AA-Pin), methotrexate (AA-Mtx) and combination of methotrexate and pinosylvin (AA-Pin+Mtx).