TABLE 2.

In vitro activity of caspofungin against 351 clinical isolates of Candida spp. resistant to fluconazole^a

Species	No. of isolates tested	Cumulative % of isolates susceptible at MIC (μg/ml)b of:
		0.03	0.06	0.12	0.25	0.5	1	2	4
C. albicans	47	0	0	30	66	74	96	98	100
C. glabrata	121	1	45	68	82	95	100
C. krusei	171	38	38	38	39	47	88	99
Candida spp.c	12	25	25	42	58	67	67	92	100
All species	351	20	35	47	58	68	92	99	100

^aFluconazole resistance was determined by NCCLS M27-A2 broth microdilution and fluconazole interpretive criteria (resistance MIC, ≥64 μg/ml).

^bCaspofungin MICs were determined by the NCCLS M27-A2 broth microdilution method.

^cC. tropicalis (three isolates), C. guilliermondii (three isolates), C. parapsilosis (four isolates), C. lusitaniae (one isolate), and C. lipolytica (one isolate).