Fig. 1.

Genetic organization and mosaic structure of multidrug-resistant plasmid pS177. Coding sequences are indicated by arrows showing the predicted direction of transcription. Position 1 of pS177 was assigned as the same nucleotide position 1 of pRUM. The origins of the components of pS177 are shown by black, white or grey arrows: genes from pRUM, black; genes from p5753cA, white; solitary insertion elements, hatched; VanA-type glycopeptide resistance gene cassette, dark grey; S. intermedius resistance gene cassette, light grey.