TABLE 5.
HPV variants identified in this study
| HPV type and variant | No. of basepair mismatches | Mutation locationa | Codon change | Protein sequence changeb | GenBank accession no. of known variant | No. of cases |
|---|---|---|---|---|---|---|
| 16 variant 1 | 1 | 5696 | AAG-AAA | Lys(46)-Lys(46) | U37217 | 8 |
| 16 variant 2 | 2 | 5637 | AGT-AGC | Ser(33)-Ser(33) | None | 2 |
| 5696 | AAG-AAA | Lys(46)-Lys(46) | ||||
| 18 variant 1 | 1 | 5701 | CCC-CGC | Pro(91)-Arg(91) | None | 4 |
| 18 variant 2 | 2 | 5619 | TTG-ATG | Leu(64)-Met(64) | None | 3 |
| 5701 | CCC-CGC | Pro(91)-Arg(91) | ||||
| 18 variant 3 | 5 | 5648 | TAT-TAC | Tyr(73)-Tyr(73) | None | 1 |
| 5684 | ACC-ACT | Thr(85)-Thr(85) | ||||
| 5701 | CCC-CGC | Pro(91)-Arg(91) | ||||
| 5729 | AGC-AGT | Ser(100)-Ser(100) | ||||
| 5789 | AAG-AAA | Lys(120)-Lys(120) | ||||
| 59 variant | 1 | 5683 | GAG-GAT | Glu(26)-Asp(26) | None | 2 |
| 39 variant | 1 | 5778 | GTA-GTG | Val(45)-Val(45) | None | 1 |
| 45 variant | 1 | 5675 | AGC-AAC | Ser(49)-Asn(49) | None | 1 |
| 52 variant | 1 | 5828 | AAA-AAG | Lys(88)-Lys(88) | None | 1 |
a
The number indicates the location of the mutation in the complete HPV viral genome given in GenBank. The GenBank accession numbers are as follows: HPV type 16, K02718; HPV type 18, X05015; HPV type 59, X77858; HPV type 39, M62849; HPV type 45, X74479; HPV type 52, X74481.
b
The numbers in parentheses represent the locations of the amino acid in the HPV L1 gene.