Figure 7.
Shunting inhibition by activation of δ-GABAARs plays a major role in suppressing the excitability of middle/high-CF neurons. A, THIP (3 μm) eliminated spontaneous APs, whereas a positive-current injection into the soma that elicited approximately the same amount of membrane depolarization did not. B, The same phenomenon was observed in presence of dendrotoxin (20–50 nm), a blocker of ILTK, which caused a dramatic increase in the background spiking activity. C, D, THIP significantly reduced the firing rate of NL neurons in the presence of dendrotoxin, whereas current injections (Iin) did not (n = 6).