Table 1.
Effects of drugs on tonic and phasic GABAergic currents in the middle/high-CF neurons
| Drugs (n) | Tonic current (pA) |
sIPSC frequency (Hz) |
sIPSC amplitude (pA) |
|||
|---|---|---|---|---|---|---|
| Control | Drug | Control | Drug | Control | Drug | |
| THIP (6) | 22.7 ± 5.8 | 74.6 ± 6.8*** | 10.1 ± 2.6 | 9.6 ± 2.5 | 41.7 ± 4.4 | 32.6 ± 3.8* |
| Flurazepam (5) | 35.5 ± 10.7 | 38.9 ± 8.8 | 11.0 ± 1.9 | 11.1 ± 1.8 | 50.7 ± 7.7 | 50.5 ± 8.0 |
| Concanamycin A | 27.6 ± 8.0 (5) | 6.9 ± 2.4 (6)* | 6.0 ± 1.0 (5) | 1.4 ± 0.5 (6)** | 55.2 ± 5.3 (5) | 38.8 ± 4.4 (6)* |
| L-655,708 (5) | 30.8 ± 6.4 | 33.1 ± 7.5 | 9.3 ± 3.6 | 9.4 ± 3.3 | 36.1 ± 8.8 | 35.8 ± 9.4 |
| 0 mm Ca2+ (5) | 19.8 ± 1.9 | 7.0 ± 2.3*** | 7.8 ± 1.8 | 4.2 ± 1.3* | 41.4 ± 9.2 | 32.6 ± 5.9 |
| Baclofen (5) | 26.7 ± 1.3 | 5.6 ± 2.1*** | 10.1 ± 0.4 | 5.6 ± 0.6** | 28.1 ± 2.6 | 29.9 ± 3.5 |
| CGP52432 (6) | 29.7 ± 4.3 | 33.8 ± 4.7 | 11.2 ± 1.5 | 11.7 ± 1.7 | 47.9 ± 8.2 | 46.2 ± 7.7 |
n, Number of cells.
*p < 0.05,
**p < 0.01, and
***p < 0.001, Student's paired t test, except that for concanamycin A, unpaired t test was used, and the number of cells is shown in parentheses after the data sets because the cells recorded under the control condition (slices pretreated in 0.5% DMSO) were different from the cells recorded under the drug condition.