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Precursor pool labeling as determined from the M2/M1 ratio for TG 54:3
| Mean ± SEM % of oleate precursor pool labeling (p) | ||||
|---|---|---|---|---|
| Time (min) | 30 | 60 | 120 | 240 |
| Vehicle | 32 ± 3 | 18 ± 1 | 12 ± 2 | 9 ± 1 |
| MTPi | 30 ± 8 | 15 ± 4 | 10 ± 2 | 8 ± 2 |
The [13C18] oleic acid label was administered (150 mg/kg) in corn oil to investigate the effects of an MTP inhibitor on distribution of isotope given as an oral bolus.
