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. Author manuscript; available in PMC: 2012 Mar 28.
Published in final edited form as: J Chem Inf Model. 2011 Mar 3;51(3):635–646. doi: 10.1021/ci100355c

Figure 9.

Figure 9

a) Proposed binding mode of compound 1 (T-226296) in the final model (Model IV). b) and c) Possible binding poses of compound 4 making contacts with hydrophobic pockets P2 or P3. d) Proposed binding interactions of compound 5. Cartoon representation was used for the backbone atoms in purple. Only residues interacting with the ligands were shown as cyan sticks. Ligands are shown as capped sticks and colored by atom types with carbon atoms in yellow. The upper part of helix 6 was truncated and only polar hydrogens are displayed for clarity.