Table 5.
Haplotype frequencies for the mannose binding lectin-2 (MBL-2) codon 52, 54, and 57 and MBLXY polymorphisms and development of acute respiratory distress syndrome (ARDS) and 60-day mortality in ARDS
| Development of ARDS |
Mortality in ARDS |
||||||||
|---|---|---|---|---|---|---|---|---|---|
| Patients With ARDS with Genotype/Total No. of Patients with Genotype (%) |
Nonsurvivors with Genotype/All ARDS Patients with Genotype (%) |
||||||||
| No. of Copies of Haplotype |
No. of Copies of Haplotype |
||||||||
| Haplotypea | Haplotype Frequencyb | 0 | 1 | 2 | p Value | 0 | 1 | 2 | p Value |
| AAAY | 0.59 | 42/107 (39) | 88/285 (30) | 62/197 (31) | .2 | 20/42 (48) | 41/86 (48) | 24/62 (39) | .5 |
| AAAX | 0.16 | 124/406 (31) | 55/158 (35) | 11/25 (44) | .3 | 54/124 (44) | 27/55 (49) | 4/11 (36) | .7 |
| DAAY | 0.09 | 165/496 (33) | 25/91 (27) | 0/2 (0) | .4 | 70/165 (42) | 15/25 (60) | 0 | .1 |
| ABAY | 0.14 | 134/422 (32) | 49/157 (31) | 7/10 (70) | <.05 | 63/134 (47) | 16/49 (33) | 6/7 (86) | .02 |
| AACY | 0.02 | 185/571 (32) | 5/17 (29) | 0/1 (0) | >.9 | 82/185 (44) | 3/5 (60) | 0 | .7 |
a
Haplotypes consist of codon 52, codon 54, codon 57, and MBLXY. The variant alleles for codon 52, 54, and 57 are D, B, and C, respectively. The wild-type allele is known collectively as the A allele
b
haplotype frequency among controls only. The p values from Fisher’s exact test for each haplotype are presented. Only the ABAY haplotype was associated with development of ARDS (p < .05) and mortality in ARDS (p = .02).