TABLE 2.
Patient-based evaluation of the AMPLICOR assay for detection of MTBa
| Study (reference) | No. of patients/specimen type | No. of MTB cultures/smear-positive patients | Gold standard used for assay's evaluation | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | Sensitivity (%) for:
|
|
|---|---|---|---|---|---|---|---|---|---|
| Smear-positive patients | Smear-negative patients | ||||||||
| Cohen et al. (19) | 85/Rç | 27/12 | Culture, clinical correlation | 74 | 93 | NA | NA | 100 | 53 |
| Al Zahrani et al. (3) | 487/Rç | 44/10 | Culture, clinical correlation | 42 | 100 | NA | NA | NA | NA |
| Bonington et al. (11) | 35/Eç | 3/3 | Culture, clinical correlation | 28.6 | 100 | 100 | 53.7 | NA | NA |
a
Abbreviations: R, respiratory specimens; E, extrapulmonary specimens; ç, manual version not including IAC; NA, not available.