TABLE 3.

Comparative studies of available CDATs for detection of MTB in clinical samples^a

Study (reference)	Method	No. of specimens/ specimen type	No. of MTB cultures/smear- positive specimens	Gold standard used for assay's evaluation	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	Sensitivity (%) for:
									Smear-positive specimens	Smear-negative specimens
Piersimoni et al. (48)	LCx	273/R	61/36	Culture, clinical correlation	75.7	98.8	96.4	90.5	91.6	58.8
		184/E	24/11	Culture, clinical correlation	53.6	99.3	93.7	92.1	81.8	35.3
	AMTD2	273/R	61/36	Culture, clinical correlation	92.8b	99.4	98.5	97	100	85.3b
		184/E	24/11	Culture, clinical correlation	78.6b	99.3	95.6	96.2	100	64.7b
Wang and Tay (64)	LCx	230/R	72/66	Culture, clinical correlation	100	99.3	98.7	100	100	100
	PCR	230/R	72/66	Culture, clinical correlation	96.1	100	100	98.1	96.9	91.7
	AMTD	230/R	72/66	Culture, clinical correlation	98.6	99.4	98.6	99.4	100	85.7
Brown et al. (12)	LCx	42/R	NA	Culture, clinical correlation	79.2	100	100	77.2	84.2	55.6
		21/E	NA	Culture, clinical correlation	60	100	100	76.5
	PCRc	42/R	NA	Culture, clinical correlation	75.0	100	100	77.5	84.2	33.3
		21/E	NA	Culture, clinical correlation	50	100	100	74
Tortoli et al. (62)	LCx	697/R+E	110/84	Culture, clinical correlation	85.7d	99.4	NA	NA	93	70.2d
	PCRc	697/R+E	110/84	Culture, clinical correlation	75.5	99.8	NA	NA	94	36.1
Scarparo et al. (57)	AMTD2	296/R	114/97	Culture, clinical correlation	85.7	100	100	90.4	91.7	65.5
		190/E	33/25	Culture, clinical correlation	82.9	100	100	95.5	88	75
	PCR	296/R	114/97	Culture, clinical correlation	94.2	100	100	96	98.9	75
		190/E	33/25	Culture, clinical correlation	85	100	100	96.1	95.8	68.7
Della-Latta and Whittier (20)	AMTD2	1385/R	62/NA	Culture, clinical correlation	97.1	99.5	NA	NA	100	92.9
	PCRc	1380/R	62/NA	Culture, clinical correlation	96.7	100	NA	NA	97.4	95.9
Piersimoni et al. (49)	AMTD2	331/R	91/76	Culture, clinical correlation	88	99.2	110e	0.11e	93.4	62.5
		184/E	30/22	Culture, clinical correlation	74.3	100	235e	0.05e	95.4	47
	DTB	331/R	91/76	Culture, clinical correlation	94.5	99.6	740e	0.26e	98.7	75
		184/E	30/22	Culture, clinical correlation	92.3f	100	920e	0.07e	100	82.3

^aAbbreviations: R, respiratory specimens; E, extrapulmonary specimens; NA, not available.

^bStatistically significant with both respiratory (P = 0.005) and extrapulmonary (P = 0.048) specimens.

^cManual version not including IAC.

^dStatistically significant with either all specimens (P = 0.026) or smear-negative (P = 0.020) specimens.

^ePositive and negative likelihood ratios.

^fStatistically significant with extrapulmonary (P = 0.03) specimens.