TABLE 6.

Evaluation of the LCx assay for detection of MTB in clinical samples^a

Study (reference)	No. of specimens/specimen type	No. of MTB cultures/smear- positive specimens	Gold standard used for assay's evaluation	Sensitivity (%)	Specificity (%)	PPV (%)	NPV (%)	Sensitivity (%) for:
								Smear-positive specimens	Smear-negative specimens
Alonso et al. (2)	322/R+E	11/8	Culture, clinical correlation	76.5	95.8	68.4	97.2	100	69.2
Palacios et al. (46)	235/E	18/0	Culture, clinical correlation	90.4	98.5	86.3	99	NA	90.4
Fadda et al. (23)	622/R+E	124/71	Culture, clinical correlation	96.8	100	100	99.2	100	79.2
Moore and Curry (44)	493/R	34/13	Culture, clinical correlation	77	99	91	98	100	56
Gamboa et al. (25)	526/E	130/33	Culture, clinical correlation	78.5	100	100	93.1	100	71.1
Garrino et al. (28)	737/R+E	61/46	Culture, clinical correlation	78	100	95	98	97.9	37.5
Lumb et al. (37)	2,347/R+E	152/79	Culture, clinical correlation	69.7	99.9	99.1	97.7	98.5	41.5
Viinanen et al. (63)	247/R	31/24	Culture, clinical correlation	83.9	97.7	83.9	97.7	96	42.8

^aAbbreviations: R, respiratory specimens; E, extrapulmonary specimens; NA, not available.