TABLE 7.
Evaluation of the BD ProbeTec assay (DTB) for detection of MTB in clinical samplesa
| Study (reference) | No. of specimens/ specimen type | No. of MTB cultures/smear-positive specimens | Gold standard used for assay's evaluation | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | Sensitivity (%) for:
|
|
|---|---|---|---|---|---|---|---|---|---|
| Smear-positive specimens | Smear-negative specimens | ||||||||
| Bergmann and Woods (7) | 523/R | 24/15 | Culture, clinical correlation | 100 | 99.2 | 85.7 | 100 | 100 | 100 |
| Pfyffer et al. (47) | 799/R | 41/28 | Culture, clinical correlation | 97.9 | 96.5 | 63.9 | 99.9 | 100 | 92.3 |
| Bergmann et al. (9) | 600/R | 16/12 | Culture, clinical correlation | 93.8 | 99.8 | 93.8 | 99.8 | 100 | 75 |
| Johansen et al. (33) | 351/R | 150/85 | Culture, clinical correlation | 82.7 | 99 | NA | NA | 100 | 60 |
| 372/E | 192/67 | Culture, clinical correlation | 60.7 | 98.9 | NA | NA | 98.5 | 40.3 | |
| Barrett et al. (6) | 200/R | 104/101 | Culture, clinical correlation | 97.1 | 96 | 97 | 96 | 99 | 33.3 |
| Maugein et al. (39) | 547/R | 69/43 | Culture, clinical correlation | 89.5 | 98.2 | 88.5 | 98.3 | 100 | 76.4 |
| 74/E | 8/4 | Culture, clinical correlation | 100 | 85.7 | |||||
| Mazzarelli et al. (40) | 537/R | 184/135 | Culture, clinical correlation | 91.3 | 98.1 | 49.2b | 0.1b | 99.2 | 70.6 |
| 294/E | 68/28 | Culture, clinical correlation | 77.8 | 97.7 | 33.3b | 0.2b | 90 | 69 | |
a
Abbreviations: R, respiratory specimens; E, extrapulmonary specimens; NA, not available.
b
Positive and negative likelihood ratios.