Table 3.
The leaky character of liposomal bilayers towards isoniazid from dialysis experiments.
| Sample | Abefore | A after | % Inc |
|---|---|---|---|
| ISO (0.1 mM control) | 0.542 ± 0.010 | 0.061 ± 0.010 | - |
| DODAB LV/ISO 0.1 mM | 0.540 ± 0.010 | 0.052 ± 0.010 | 0 |
| DODAB/DPPC 1:1/ISO 0.1 mM | 0.504 ± 0.010 | 0.058 ± 0.010 | 0 |
| ISO (10.0 mM control) | 20.00 ± 0.010 | 0.017 ± 0.010 | - |
| ASO MLV/ISO 10 mM | 19.50 ± 0.010 | 0.400 ± 0.010 | 0.01 |
Isoniazid incorporation in DODAB, DODAB/DPPC 1:1 or asolecithin (ASO) liposomal dispersions from ISO absorbance at 260 nm (A) before and after dialysis. Final lipid concentration was 2.0 mM.