Table 1. New inhibitors of PBPs from resistant bacteria.^a .

Compound	PBP2a RA [%] (IC50)	PBP2x5204 RA [%] (IC50)	PBP5fm RA [%] (IC50)
1	0 (97 µM)	38b (391 µM)	100
2	58	123	39 (930 µM)
3	67	80	65
4	83	101	100
5	86	81	73
6	0 (210 µM)	41	68
7	74	65	72
8	60	103	74
9	0 (230 µM)	8b (155 µM)	72
10	17 (680 µM)	121	69
11	70	118	61
12	47 (910 µM)	97	34 (>1 mM)

^aThe data represent mean values of three independent experiments. Standard deviations were within ±10% of these mean values. RA = residual activity of the enzyme at 1 mM inhibitor, unless stated otherwise. IC₅₀-values were determined in the presence of 0.01% Triton X-100. ^bResidual activity of the enzyme at 500 µM inhibitor.