Table 3.

Proteins reduced in colon tumor vs. non-tumor tissue.

Protein ID	Symbol	Ave spec	Ave spec	T/N	p-value	Description
Actinomyosin complex and cell-matrix interaction
NP_001074776	Ppp1r12b	12.78	3.44	0.27	0.0146	protein phosphatase 1 regulatory subunit
NP_109617	Sacm1l	8.44	2.33	0.28	0.0137	SAC1 (suppressor of actin mutations 1,
XP_619639	Tns1	38.06	11.67	0.31	0.0198	PREDICTED: tensin 1
NP_964001	Synm	179.94	80.89	0.45	0.0258	desmuslin isoform H and H
NP_034052	Cnn1	777.56	381.33	0.49	0.0027	calponin 1
NP_647461	Mylk	230.11	121.00	0.53	0.0015	myosin, light polypeptide kinase
XP_485171	Myl9	223.92	127.78	0.57	0.0478	PREDICTED: similar to Myosin, light
NP_663550	Cald1	137.19	81.92	0.60	0.0476	caldesmon 1
NP_075891	Mylc2b	269.72	166.28	0.62	0.0023	myosin light chain, regulatory B
NP_001030136	Sorbs1	76.28	36.08	0.47	0.0305	sorbin and SH3 domain containing 1
NP_604443	Dst	39.53	14.25	0.36	0.0143	dystonin isoforms a and b
NP_062733	Dpt	11.28	4.11	0.36	0.0274	dermatopontin
Oxidative stress response, metabolism and detoxification
NP_598755	Gstt3	9.61	3.67	0.38	0.0151	glutathione S-transferase, theta 3
NP_031646	Cbr1	119.03	71.97	0.60	0.0441	carbonyl reductase 1
NP_964004	Ugt1a7c	31.53	3.17	0.10	0.0276	UDP glucuronosyltransferase 1 family,
NP_080979	Ndufa8	15.53	6.44	0.42	0.0165	NADH dehydrogenase (ubiquinone) 1
NP_033463	Tst	25.78	12.67	0.49	0.0256	thiosulfate sulfotransferase,
NP_084501	Dlst	23.33	12.67	0.54	0.0001	dihydrolipoamide S-succinyltransferase
NP_663533	Hadhb	66.14	40.06	0.61	0.0390	mitochondrial trifunctional protein, beta
NP_031520	Ass1	30.61	16.17	0.53	0.0024	argininosuccinate synthetase
NP_084280	Cryl1	22.89	8.72	0.38	0.0369	crystallin, lambda 1
NP_083907	Abhd14b	12.89	6.11	0.47	0.0350	abhydrolase domain containing 14b
Signal transduction and regulatory pathways
NP_062650	Plcd1	6.00	2.56	0.43	0.0345	phospholipase C, delta 1
NP_033176	Selenbp1	223.50	75.00	0.34	0.0326	selenium binding protein 1
NP_031720	Chgb	10.89	2.22	0.20	0.0248	chromogranin B