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. Author manuscript; available in PMC: 2012 Jun 1.
Published in final edited form as: Biol Psychiatry. 2011 Apr 8;69(11):1067–1074. doi: 10.1016/j.biopsych.2011.02.014

Figure 4.

Figure 4

Dampened dopamine release during the 45-min period prior to cocaine availability. (A) Example of trial-by-trial changes in dopamine concentration during a baseline period prior to intraoral saccharin infusions of the unpaired tastant. High-concentration transients (red) are randomly distributed across time (abscissa) and trials (ordinate). (B) Example of trial-by-trial changes in dopamine concentration transients during the baseline period prior to intraoral infusions of the cocaine-predictive tastant. (C) Average dopamine concentration (mean ± sem) in the baseline period for all animals receiving the unpaired tastant is stable across trials (Early vs Late), P>0.05. (D) Dopamine concentration decreased significantly across trials for rats receiving the cocaine-predictive taste cue, P<0.05.