TABLE 2.
Components of posttranscriptional gene silencing
| Phenomenon | Organism | Mutation causing defective silencing | Gene function | Developmental defect |
|---|---|---|---|---|
| Posttranscriptional | Plant (Arabidopsis thaliana) | sgs2/sde1 | RdRP | None |
| gene silencing | sgs3 | Unknown function | None | |
| sde3 | RecQ helicase | |||
| ago1 | Translation initiation factor | Pleiotropic effects on development & fertility | ||
| caf1 | RNA helicase & RNase III | |||
| Quelling | Fungus (Neurospora crassa) | qde-1 | RdRP | None |
| qde-2 | Translation initiation factor | None | ||
| qde-3 | RecQ DNA helicase | |||
| RNA interference | Worm (Caenorhabditis elegans) | ego-1 | RdRP | Gametogenetic defect & sterility |
| rde-1 | Translation initiation factor | None | ||
| rde-2, rde-3, rde-4, mut-2 | Unknown function | None | ||
| K12H4.8 (dcr-1) | Dicer homologue RNA helicase & RNase III | Sterility | ||
| mut-7 | Helicase & RNase D | None | ||
| mut-14 | DEAD box RNA helicase | |||
| smg-2 | Upflp helicase | |||
| smg-5 | Unknown function | |||
| smg-6 | Unknown function | |||
| sid-1 | Transmembrane protein | |||
| Alga (Chlamydomonas reinhardtii) | mut-6 | DEAH box RNA helicase |