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. 2003 Dec;67(4):593–656. doi: 10.1128/MMBR.67.4.593-656.2003

FIG. 2.

FIG. 2.

Structure of the OmpF porin of E. coli. (A) View of the trimer from the top, that is, in a direction perpendicular to the plane of the membrane. Loop 2, colored blue, plays a role in interaction of the monomer with its neighboring unit. Loop 3, colored orange, narrows the channel. (B) View of the monomeric unit from the side, roughly in the direction of the arrow in panel A. Loops 2 and 3 are colored as in panel A. (C) View of the monomeric unit from the top, showing the “eyelet” or the constricted region of the channel. The eyelet is formed by Glu117 and Asp113 from the L3 loop, as well as four basic residues from the opposing barrel wall, Lys16, Arg42, Arg82, and Arg132, all shown as spheres. The diagrams are based on PDB file 2OMF. This figure and Fig. 4 and 6 were drawn by using the program PyMol (Warren L. DeLano, DeLano Scientific LLC, San Carlos, Calif. [http://www.pymol.org]).