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. Author manuscript; available in PMC: 2012 Jun 1.
Published in final edited form as: Biol Psychiatry. 2011 Feb 21;69(11):1083–1090. doi: 10.1016/j.biopsych.2010.12.030

Figure 5. Actions of repeated in vivo cocaine on excitatory effects of urocortin are absent during withdrawal.

Figure 5

A) Diagrammatic representation of the experimental setup. Mice were given either 10 days of ip cocaine (20mg/kg) or saline followed by 10 days of withdrawal. On the tenth day after there last injection brain slices were prepared for electrophysiological recordings.

B) In mice receiving 10 days of cocaine (red) bath application of 300 nM urocortin produces a modest increase in sEPSC frequency and similarly increases it in those mice receiving saline (black).