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. Author manuscript; available in PMC: 2012 Jun 1.
Published in final edited form as: Biol Psychiatry. 2011 Feb 21;69(11):1083–1090. doi: 10.1016/j.biopsych.2010.12.030

Figure 6. Urocortin enhancement of excitatory transmission is disrupted by a cocaine challenge during withdrawal.

Figure 6

A) Diagrammatic representation of the experimental setup. Mice were given either 10 days of ip cocaine (20mg/kg) or saline followed by 10 days of withdrawal. On the tenth day of withdrawal all animals received a challenge injection of cocaine (20mg/kg) and brain slices were prepared 30 minutes following this injection.

B) In mice who had received 10 days of cocaine before the challenge (red) bath application of 300 nM urocortin had no effect on sEPSC frequency but increases it in those mice who had received saline (black).