| Total LUTS |
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| Voiding symptoms |
AUA-SI score ≥ 5 (of total possible 20 points) on four questions regarding intermittency, weak urinary stream, hesitancy, and incomplete bladder emptying
Continuous voiding symptom score (secondary outcome)
For exploratory analyses of individual AUA-SI voiding symptoms, response of “fairly often,” “usually” or “almost always” to the respective AUA-SI question
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| Storage symptoms |
AUA-SI score ≥ 4 (of total possible 15 points) on three questions regarding frequency, urgency, and nocturia
Continuous storage symptom score (secondary outcome)
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For exploratory analyses of individual symptoms:
Frequency: “frequent urination during the day” or “to urinate again less than two hours after you finished urinating” fairly often or more in the last month
Urgency: “a strong urge or pressure to urinate that signals the need to urinate” four or more times in the last 7 days, or “difficulty postponing urination” fairly often or more in the last month
Nocturia was defined in two ways based on number of times respondent gets out of bed at night after falling asleep to urinate: 1) at least once, 2) at least twice.
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| Post-micturition symptoms |
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Feeling of incomplete emptying and/or post-micturition dribble, as assessed by a positive response to at least one of the following (experienced fairly often, usually or almost always):
Sensation of not completely emptying the bladder after having finished urinating, and/or
Experiencing dribbling after urination.
Continuous symptom score, created by summing responses to two questions above indicating how frequently symptoms occur (possible range, 0–10)
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| Urinary incontinence |
Score > 3 on the Sandvik severity index (39), which assesses urine leakage frequency (< once/month, one or more times per month, one or more a times per week, or everyday) and amount (drops, small splashes, or more), resulting in a composite score ranging from one to twelve. A severity score ≥ 3 indicates moderate-to-severe UI and corresponds to at least weekly leakage or monthly leakage of volumes more than a few drops in the past 12 months (40–42).
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