Skip to main content
. Author manuscript; available in PMC: 2012 Jun 1.
Published in final edited form as: Dev Biol. 2011 Apr 2;354(1):102–110. doi: 10.1016/j.ydbio.2011.03.025

Fig. 7. Model for mesoderm maturation and the role of Spadetail.

Fig. 7

Schematic illustration of lateral mesoderm during gastrulation, with cell shapes exaggerated for clarity. (1) Mesodermal progenitors are located in the epiblast layer and marked by expression of ntl. (2) As cells approach the margin the maturation program is initiated, which includes transcription of spt. As cells involute to join the deeper cell layers they enter the transition state and bleb extensively. (3) Cells require Spadetail to reduce blebbing and leave the transition state. Cells down-regulate ntl and other progenitor genes, and activate the expression of Spadetail targets such as tbx24 and papc.