Fig. 3.

Plots of thrombus reduction and bleeding time versus dose in apixaban, rivaroxaban, dabigatran and warfarin-treated rabbits. Thrombus reduction, measured in the prevention model of venous thrombosis, was expressed as the percentage reduction in thrombus weight after treatment, relative to the mean vehicle thrombus weight. Bleeding time effect was expressed as a ratio of treated versus the mean vehicle value. Data are mean ± SE (n = 6 per group for the thrombosis and bleeding time studies and n = 12 per dose for plasma concentrations) (data from Wong et al. [7, 15]; reproduced with permission). Reproduced from “Favorable therapeutic index of the direct factor Xa inhibitors, apixaban and rivaroxaban, compared with the thrombin inhibitor dabigatran in rabbits” published in “Journal of Thrombosis and Haemostasis” (2009), John Wiley and Sons; and from "Apixaban, an oral, direct and highly selective factor Xa inhibitor: in vitro, antithrombotic and antihemostatic studies" published in “Journal of Thrombosis and Haemostasis” (2008), John Wiley and Sons