Fig. 5.

Plots of thrombus reduction (bar graph) and ex vivo clotting times (line graph) in apixaban-treated rabbits. Thrombus reduction, measured in the prevention model of venous thrombosis, was expressed as the percentage reduction in thrombus weight after treatment, relative to the mean vehicle thrombus weight (data from Fig. 3). For clarity, only mean data for thrombus reduction and the bolus dose (mg/kg) are shown. Activated partial thromboplastin time (aPTT), prothrombin time (PT), modified prothrombin time (mPT) and thrombin time (TT) were expressed as the treated/control ratio. Data are mean ± SE (n = 6 per group for thrombus reduction and n = 12 per group for clotting times) (data from Wong et al. [7]; reproduced with permission). Reproduced from “Favorable therapeutic index of the direct factor Xa inhibitors, apixaban and rivaroxaban, compared with the thrombin inhibitor dabigatran in rabbits” published in “Journal of Thrombosis and Haemostasis” (2009), John Wiley and Sons