Ex vivo anti-FXa and anti-thrombin effects of apixaban in arterial thrombosis rabbits from Fig. 4 (top) and correlation of ex vivo anti-FXa with antithrombotic effects and plasma concentrations of apixaban in arterial thrombosis rabbits (bottom). *P < 0.05, compared with the vehicle. Mean ± SE and n = 6 per group (data from Wong et al. [15]; reproduced with permission). Reproduced from "Apixaban, an oral, direct and highly selective factor Xa inhibitor: in vitro, antithrombotic and antihemostatic studies" published in “Journal of Thrombosis and Haemostasis” (2008), John Wiley and Sons