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In vitro Ki values for inhibition of human enzymes by apixaban at 25°C [13]
| Enzyme | Ki (nM) |
|---|---|
| Factor Xa | 0.08 ± 0.03 |
| Activated protein C | >30,000 |
| Chymotrypsin | 3,500 |
| Factor IXa | >15,000 |
| Factor VIIa | >15,000 |
| Plasma kallikrein | 3,700 |
| Plasmin | >25,000 |
| Thrombin | 3,100 |
| Tissue plasminogen activator | >40,000 |
| Trypsin | >20,000 |
