Table 2.
In vitro potency (Ki) of apixaban against human, rabbit, rat and dog factor Xa (FXa) and the concentrations required to double (EC2×) the prothrombin time (PT), modified prothrombin time (mPT), activated partial thromboplastin time (aPTT) and HepTest in human, rabbit, rat or dog plasma [15]
| Species | FXa Ki (nM) | PT EC2× (μM) | mPT EC2× (μM) | aPTT EC2× (μM) | HepTest EC2× (μM) |
|---|---|---|---|---|---|
| Human | 0.081 ± 0.002 | 3.6 | 0.37 | 7.4 | 0.4 |
| Rabbit | 0.16 ± 0.01 | 2.3 | 0.6 | 4.8 | 1.8 |
| Rat | 1.3 ± 0.1 | 7.9 | n.d. | 20 | n.d. |
| Dog | 1.7 ± 0.2 | 6.7 | n.d. | >20 | n.d. |
n.d. not determined