Table 3.

Potency of apixaban in multiple thrombosis models

Species	Modela	ID50 (mg/kg/h)b	IC50 (μM)b
Ratc	AV-ST	1.20	5.71
	TF-VT	1.55	7.57
	FeCl2-VT	0.39	1.84
	FeCl2-AT	0.72	3.23
Rabbitd	AV-ST	0.27	0.36
	pDVT	0.11	0.065
	ECAT	0.07	0.11

^aExperimental models included arterial-venous shunt thrombosis (AV-ST), tissue factor-stasis venous thrombosis (TF-VT), FeCl₂-induced vena cava thrombosis (FeCl₂-VT), carotid artery thrombosis (FeCl₂-AT), prevention model of deep vein thrombosis (pDVT) and electrically induced carotid arterial thrombosis (ECAT)

^bPotency for 50% decrease in thrombus weight was determined for concentration (IC₅₀) and dose (ID₅₀)

^cData from Schumacher et al. [42]

^dData from Wong et al. [7, 15]